The cells test "negative" on all 3 tests. These cancers tend to be more common in women younger than age 40, who are African-American, or who have a BRCA1 mutation. Triple-negative breast cancer differs from other types of invasive breast cancer in that they grow and spread faster, have limited treatment options, and a worse prognosis outcome. Once a breast cancer diagnosis has been made using imaging tests and a biopsy , the cancer cells will be checked for certain features. If the cells do not have estrogen or progesterone receptors, and also do not make too much of the HER2 protein, the cancer is considered to be triple-negative breast cancer.
Triple-negative breast cancer: What you need to know
Triple-negative breast cancer is cancer that tests negative for estrogen receptors, progesterone receptors, and excess HER2 protein. These results mean the growth of the cancer is not fueled by the hormones estrogen and progesterone, or by the HER2 protein. So, triple-negative breast cancer does not respond to hormonal therapy medicines or medicines that target HER2 protein receptors. Still, other medicines are used to successfully treat triple-negative breast cancer. For doctors and researchers, there is intense interest in finding new medications that can treat this kind of breast cancer. Studies are trying to find out whether certain medications can interfere with the processes that cause triple-negative breast cancer to grow.
This means that the breast cancer cells have tested negative for hormone epidermal growth factor receptor 2 HER-2 , estrogen receptors ER , and progesterone receptors PR. In fact, triple negative breast cancer may respond even better to chemotherapy in the earlier stages than many other forms of cancer. Triple negative breast cancer can be more aggressive and difficult to treat. Also, the cancer is more likely to spread and recur. Material on this page courtesy of Johns Hopkins Medicine.
Triple-negative breast cancer is a kind of breast cancer that does not have any of the receptors that are commonly found in breast cancer. Think of cancer cells as a house. The front door may have three kinds of locks, called receptors —.