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Get e-Alerts Abstract This paper presents an experimental and numerical investigation into electrokinetic focusing injection on microfluidic chips. The valving characteristics on microfluidic devices are controlled through appropriate manipulations of the electric potential strengths during the sample loading and dispensing steps. The present study also addresses the design and testing of various injection systems used to deliver a sample plug. A novel double-cross injection microfluidic chip is fabricated, which employs electrokinetic focusing to deliver sample plugs of variable volume. The proposed design combines several functions of traditional sample plug injection systems on a single microfluidic chip.
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A new ultimate anus-preserving operation for extremely low rectal cancer and for anal canal cancer

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Metrics details Abstract. To avoid permanent colostomy, we perform a new ultimate anus preserving operation for extremely low rectal cancer or for anal canal cancer. According to our pathologic study, two different removal methods of anal canal were theoretically considered. One is internal sphincter resection ISR method , and the other is both deep-superficial external sphincter and internal sphincter resection ESR method. No severe intraoperative complications occurred and the postoperative course was uneventful. All patients receiving ISR had excellent anal function without soiling. Some patients receiving ESR sometimes complained of night soiling but satisfied the anus preservation.
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Diagnosis and Management of Patients with Anal Fissures

Patients with anal fissures usually present with pain and bleeding. Pain is often most severe during or after a bowel movement, while bleeding is usually bright red and minimal. An accurate diagnosis can often be made on the basis of the patient's history.
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Background[ edit ] Legal punishments for sodomy often included heavy fines, prison sentences, or both, with some states, beginning with Illinois in , denying other rights, such as suffrage , to anyone convicted of the crime of sodomy. As late as , Connecticut denied a driver's license to a man for being an "admitted homosexual". In Griswold v. Connecticut , the Supreme Court struck down a law barring the use of contraceptives by married couples.
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